Pub. Date : 1997 Jan
PMID : 9024172
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The effect of valsartan on the angiotensin II pressor response in healthy normotensive male subjects. | Valsartan | angiotensinogen | Homo sapiens |
| 2 | OBJECTIVE: Valsartan is an oral antagonist of angiotensin II that competes with angiotensin II for the AT1-receptor and is being developed as an antihypertensive agent. | Valsartan | angiotensinogen | Homo sapiens |
| 3 | OBJECTIVE: Valsartan is an oral antagonist of angiotensin II that competes with angiotensin II for the AT1-receptor and is being developed as an antihypertensive agent. | Valsartan | angiotensinogen | Homo sapiens |
| 4 | This study assessed the ability of 80 mg valsartan to inhibit the pressor effect of exogenous angiotensin II in healthy normotensive men, first after a single dose and then after multiple doses once daily for 7 days. | Valsartan | angiotensinogen | Homo sapiens |
| 5 | RESULTS: Systolic blood pressure responses to angiotensin II challenges after single and multiple doses of valsartan were significantly lower than placebo, indicating that valsartan blocked the blood pressure response to angiotensin II. | Valsartan | angiotensinogen | Homo sapiens |
| 6 | RESULTS: Systolic blood pressure responses to angiotensin II challenges after single and multiple doses of valsartan were significantly lower than placebo, indicating that valsartan blocked the blood pressure response to angiotensin II. | Valsartan | angiotensinogen | Homo sapiens |
| 7 | The angiotensin II blocking effect was maintained up to this time, despite low plasma valsartan levels and minimal accumulation after multiple doses. | Valsartan | angiotensinogen | Homo sapiens |
| 8 | CONCLUSION: Valsartan, 80 mg, is a potent angiotensin II antagonist with a rapid onset of action and persistent angiotensin II inhibition up to 24 hours. | Valsartan | angiotensinogen | Homo sapiens |
| 9 | CONCLUSION: Valsartan, 80 mg, is a potent angiotensin II antagonist with a rapid onset of action and persistent angiotensin II inhibition up to 24 hours. | Valsartan | angiotensinogen | Homo sapiens |