Title : Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation.

Pub. Date : 1997 Feb

PMID : 9023313






1 Functional Relationships(s)
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Protein Name
Organism
1 Testosterone 6beta-hydroxylation (mediated by CYP3A4), 7-ethylresorufin O-deethylation (CYP1A2) and tolbutamide methyl hydroxylation (CYP2C9/10), but not aniline 4-hydroxylation (CYP2E1), were inhibited effectively by parathion. Testosterone cytochrome P450 family 3 subfamily A member 4 Homo sapiens