Pub. Date : 1997 Feb 1
PMID : 9022075
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Human neutrophils employ the myeloperoxidase-hydrogen peroxide-chloride system to convert hydroxy-amino acids into glycolaldehyde, 2-hydroxypropanal, and acrolein. | Chlorides | myeloperoxidase | Homo sapiens |
2 | We now demonstrate that human neutrophils employ the myeloperoxidase-H202-chloride system to produce alpha-hydroxy and alpha,beta-unsaturated aldehydes from hydroxy-amino acids in high yield. | Chlorides | myeloperoxidase | Homo sapiens |
3 | Aldehyde production by purified myeloperoxidase required H202 and chloride, and was mimicked by reagent hypochlorous acid (HOCl) in the absence of enzyme, suggesting that the reaction pathway involves a chlorinated intermediate. | Chlorides | myeloperoxidase | Homo sapiens |
4 | Collectively, these results indicate that the myeloperoxidase-H202-chloride system of phagocytes converts free hydroxy-amino acids into highly reactive alpha-hydroxy and alpha,beta-unsaturated aldehydes. | Chlorides | myeloperoxidase | Homo sapiens |