Title : Phase I trial of etoposide, carboplatin, and GM-CSF in extensive small-cell lung cancer: a Cancer and Leukemia Group B study (CALGB 8832).

Pub. Date : 1997 Feb

PMID : 9020283






4 Functional Relationships(s)
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1 The purpose of this phase I trial was to determine if granulocyte macrophage colony-stimulating factor (GM-CSF) support allows the dosage of the combination of etoposide and carboplatin to be increased above the previously determined MTD. Etoposide colony stimulating factor 2 Homo sapiens
2 The purpose of this phase I trial was to determine if granulocyte macrophage colony-stimulating factor (GM-CSF) support allows the dosage of the combination of etoposide and carboplatin to be increased above the previously determined MTD. Etoposide colony stimulating factor 2 Homo sapiens
3 With 5 microg/kg/d GM-CSF, the first etoposide and carboplatin cycle of 300 and 150 mg/m2/day x 3, respectively, could be administered with acceptable toxicity. Etoposide colony stimulating factor 2 Homo sapiens
4 These results demonstrate that GM-CSF alone has limited capability to support the repeated administration of high doses of etoposide and carboplatin. Etoposide colony stimulating factor 2 Homo sapiens