Title : Defects in p21WAF1/CIP1, Rb, and c-myc signaling in phorbol ester-resistant cancer cells.

Pub. Date : 1997 Jan 15

PMID : 9000576






2 Functional Relationships(s)
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1 We show that despite p21 induction in 7 of 12 human cancer cell lines treated with PMA, growth inhibition was observed only in two cell lines (SKBr3 breast and LNCaP prostate cancer cells). Tetradecanoylphorbol Acetate H3 histone pseudogene 16 Homo sapiens
2 Our findings suggest that induction of p21 and down-regulation of c-myc may be necessary steps in a PMA-induced growth-inhibitory pathway in cancer cells. Tetradecanoylphorbol Acetate H3 histone pseudogene 16 Homo sapiens