Title : Characterization of the Saccharomyces cerevisiae FCY1 gene encoding cytosine deaminase and its homologue FCA1 of Candida albicans.

Pub. Date : 1997 Jan

PMID : 9000374






3 Functional Relationships(s)
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Protein Name
Organism
1 Disruption of FCY1 resulted in high resistance to 5-fluorocytosine (10(-2) M) and in total loss of cytosine deaminase activity. Flucytosine cytosine deaminase Saccharomyces cerevisiae S288C
2 By contrast the transformation by FCY1 or FCA1 of the haploid FCY1-disrupted host strain restored sensitivity to 5-fluorocytosine and allowed growth on cytosine, as a source of pyrimidine, or ammonium. Flucytosine cytosine deaminase Saccharomyces cerevisiae S288C
3 By contrast the transformation by FCY1 or FCA1 of the haploid FCY1-disrupted host strain restored sensitivity to 5-fluorocytosine and allowed growth on cytosine, as a source of pyrimidine, or ammonium. Flucytosine cytosine deaminase Saccharomyces cerevisiae S288C