Pub. Date : 1996 Dec 19
PMID : 8997601
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effects of galanin on 8-OH-DPAT induced decrease in body temperature and brain 5-hydroxytryptamine metabolism in the mouse. | 8-Hydroxy-2-(di-n-propylamino)tetralin | galanin and GMAP prepropeptide | Mus musculus |
| 2 | 8-OH-DPAT (0.5 mg/kg s.c.) also decreased cortical and hypothalamic 5-HT (5-hydroxytryptamine, serotonin) metabolism, an effect which was not blocked by pretreatment with galanin (0.3-3 nmol intracerebroventricular, i.c.v.). | 8-Hydroxy-2-(di-n-propylamino)tetralin | galanin and GMAP prepropeptide | Mus musculus |
| 3 | These results suggest that the inhibition of 8-OH-DPAT induced hypothermia by galanin is probably not mediated by an interaction with 5-HT1A receptors but more likely by blocking the indirect activation by 8-OH-DPAT of central cholinergic pathways involved in temperature regulation. | 8-Hydroxy-2-(di-n-propylamino)tetralin | galanin and GMAP prepropeptide | Mus musculus |
| 4 | These results suggest that the inhibition of 8-OH-DPAT induced hypothermia by galanin is probably not mediated by an interaction with 5-HT1A receptors but more likely by blocking the indirect activation by 8-OH-DPAT of central cholinergic pathways involved in temperature regulation. | 8-Hydroxy-2-(di-n-propylamino)tetralin | galanin and GMAP prepropeptide | Mus musculus |