Pub. Date : 1997 Jan
PMID : 8996200
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Although TPA alone did not support colony formation, TPA in combination with IL-3 increased colony numbers from 1.5 to 2 times that formed with IL-3 and vehicle. | Tetradecanoylphorbol Acetate | interleukin 3 | Mus musculus |
| 2 | Because TPA enhanced IL-3-dependent colony formation derived from lineage-negative marrow cells obtained from mice that received 5-FU 2 days before, it is possible that it might act directly on primitive progenitors. | Tetradecanoylphorbol Acetate | interleukin 3 | Mus musculus |
| 3 | Calphostin C, a specific PKC inhibitor, and certain specific tyrosine kinase inhibitors, such as genistein and herbimycin A, abrogated the enhancing effects of TPA on IL-3-dependent colony formation. | Tetradecanoylphorbol Acetate | interleukin 3 | Mus musculus |
| 4 | These data suggest that TPA had a direct effect on the primitive progenitors and enhanced IL-3-dependent colony formation via activation of PKC and certain tyrosine kinases. | Tetradecanoylphorbol Acetate | interleukin 3 | Mus musculus |