Title : Dose-escalation and pharmacodynamic study of topotecan in combination with cyclophosphamide in patients with refractory cancer.

Pub. Date : 1997 Jan

PMID : 8996136






3 Functional Relationships(s)
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1 Once the MTD was defined, granulocyte colony-stimulating factor (G-CSF) was added to the regimen in an attempt to escalate further the dose of topotecan. Topotecan colony stimulating factor 3 Homo sapiens
2 Once the MTD was defined, granulocyte colony-stimulating factor (G-CSF) was added to the regimen in an attempt to escalate further the dose of topotecan. Topotecan colony stimulating factor 3 Homo sapiens
3 CONCLUSION: For previously treated patients, the recommended dose of topotecan in this schedule is 0.75 mg/m2/d without growth factor support and 1.0 mg/ m2/d if it is administered with G-CSF. Topotecan colony stimulating factor 3 Homo sapiens