Title : Insulin-like growth factor I enhancement of steroidogenesis by bovine granulosa cells and thecal cells: dependence on de novo cholesterol synthesis.

Pub. Date : 1996 Dec

PMID : 8994382






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Simvastatin, a potent inhibitor of the key enzyme controlling de novo cholesterol synthesis, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, completely inhibited (P < 0.05) progesterone production by granulosa cells and progesterone and androstenedione production by thecal cells. Progesterone 3-hydroxy-3-methylglutaryl-CoA reductase Bos taurus