Title : GnRH-stimulated glycosylation (proximal and distal) of luteinizing hormone by cultured rat pituitary cells.

Pub. Date : 1996 Dec

PMID : 8990079






2 Functional Relationships(s)
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1 Comparatively, the effect of GnRH on [3H]Gal-LH was detected earlier than that on LH labeled with the other precursors; increases in rates of production (slope = 71.57; 278% of control) and release (slope = 32.08; 494%) were higher than those in [14C]Leu- and [3H]Man-LH kinetics, indicating that GnRH acts specifically on this distal step of LH glycosylation. Leucine gonadotropin releasing hormone 1 Homo sapiens
2 GnRH enhanced the relative terminal glycosylation ([3H]Gal/[14C]Leu ratio) of total and release LH without modifying the relative proximal glycosylation ([3H]Man/[14C]Leu ration) of the hormone. Leucine gonadotropin releasing hormone 1 Homo sapiens