Pub. Date : 1996 Nov 28
PMID : 8982652
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In whole blood, flurbiprofen was approximately 10-fold more potent that flurbinitroxybutylester to inhibit the cyclooxygenase activity of platelet prostaglandin endoperoxide synthase-1 (IC50 microM: 0.90 +/- 0.27 vs. 10.70 +/- 5, mean +/- S.D., P < 0.05). | Flurbiprofen | prostaglandin-endoperoxide synthase 1 | Homo sapiens |
| 2 | In whole blood, flurbinitroxybutylester was slowly converted to flubiprofen and this in turn could influence the extent of inhibition of the cyclooxygenase activity of prostaglandin endoperoxide synthase-1. | Flurbiprofen | prostaglandin-endoperoxide synthase 1 | Homo sapiens |
| 3 | In conclusion, the addition of a nitroxybutyl moiety to flurbiprofen seems to reduce its capacity to inhibit the cyclooxygenase activity of prostaglandin endoperoxide synthase-1. | Flurbiprofen | prostaglandin-endoperoxide synthase 1 | Homo sapiens |