Title : A possible structural determinant of selectivity of boldine and derivatives for the alpha 1A-adrenoceptor subtype.

Pub. Date : 1996 Dec

PMID : 8982502






1 Functional Relationships(s)
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1 These results suggest that whereas the aporphine structure shared by these alkaloids is responsible for their selectively of action for the alpha 1A-adrenoceptor subtype in rat cerebral cortex, defined functional groups, namely the 2-hydroxy function, induces a significant increase in alpha 1A-subtype selectivity and affinity. Alkaloids adrenoceptor alpha 1A Rattus norvegicus