Title : Synthesis and bioevaluation of delta 7-5-desaturase inhibitors, an enzyme late in the biosynthesis of the fungal sterol ergosterol.

Pub. Date : 1996 Dec 20

PMID : 8978840






1 Functional Relationships(s)
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1 The delta 5-double bond appears to be required for the regulatory role of ergosterol; therefore, development of inhibitors of the enzyme that introduce this double bond, delta 7-sterol 5-desaturase (5-desaturase), may lead to effective antifungal agents. Ergosterol sterol-C5-desaturase Homo sapiens