Title : Inhibitors of histamine methylation in brain promote formation of imidazoleacetic acid, which interacts with GABA receptors.

Pub. Date : 1997 Jan

PMID : 8978720






9 Functional Relationships(s)
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1 But in brain, histamine is thought to be metabolized solely by histamine methyltransferase (HMT), forming tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA). Histamine histamine N-methyltransferase Rattus norvegicus
2 But in brain, histamine is thought to be metabolized solely by histamine methyltransferase (HMT), forming tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA). Histamine histamine N-methyltransferase Rattus norvegicus
3 We showed that [3H]-histamine (intracerebroventricularly) could be converted to IAA in brains of rats, a process increased by inhibition of HMT. Histamine histamine N-methyltransferase Rattus norvegicus
4 This demonstrated that brain can oxidize histamine and suggested that endogenous histamine might also be oxidized if HMT activity were reduced. Histamine histamine N-methyltransferase Rattus norvegicus
5 This demonstrated that brain can oxidize histamine and suggested that endogenous histamine might also be oxidized if HMT activity were reduced. Histamine histamine N-methyltransferase Rattus norvegicus
6 To measure histamine in tissue that contained HMT inhibitors, we developed a gas chromatography-mass spectrometry method. Histamine histamine N-methyltransferase Rattus norvegicus
7 Our results show that inhibition of HMT promotes oxidation of histamine in brain, probably by shunting histamine to an alternative metabolic pathway. Histamine histamine N-methyltransferase Rattus norvegicus
8 Our results show that inhibition of HMT promotes oxidation of histamine in brain, probably by shunting histamine to an alternative metabolic pathway. Histamine histamine N-methyltransferase Rattus norvegicus
9 Accumulation of IAA should be considered when inhibitors of HMT are used to probe brain histamine function. Histamine histamine N-methyltransferase Rattus norvegicus