Pub. Date : 1997 Jan 1
PMID : 8978305
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have mapped the site of interaction of CRKL and BCR-ABL to the amino terminal SH3 domain of CRKL with a proline rich region in the C-terminus of ABL. | Proline | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 2 | We have mapped the site of interaction of CRKL and BCR-ABL to the amino terminal SH3 domain of CRKL with a proline rich region in the C-terminus of ABL. | Proline | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 3 | The proline-rich region was mutated and the effect of this deletion on BCR-ABL transforming function was assayed. | Proline | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 4 | In cells expressing the proline deletion mutation of BCR-ABL, CRKL is still tyrosine phosphorylated and forms a complex with BCR-ABL as demonstrated by coimmunoprecipitation. | Proline | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 5 | In cells expressing the proline deletion mutation of BCR-ABL, CRKL is still tyrosine phosphorylated and forms a complex with BCR-ABL as demonstrated by coimmunoprecipitation. | Proline | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 6 | Our data suggest that the interaction between CRKL and the proline deletion mutant of BCR-ABL is an indirect interaction as CRKL does not interact directly with the proline deletion mutant of BCR-ABL in a gel overlay assay or in a yeast two-hybrid assay. | Proline | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |
| 7 | Our data suggest that the interaction between CRKL and the proline deletion mutant of BCR-ABL is an indirect interaction as CRKL does not interact directly with the proline deletion mutant of BCR-ABL in a gel overlay assay or in a yeast two-hybrid assay. | Proline | ABL proto-oncogene 1, non-receptor tyrosine kinase | Homo sapiens |