Title : Effects of glucocorticoids on lymphocyte activation in patients with steroid-sensitive and steroid-resistant asthma.

Pub. Date : 1996 Dec

PMID : 8977508






3 Functional Relationships(s)
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1 Peripheral blood mononuclear cell GCR binding affinities for dexamethasone and budesonide were also determined for both patient groups by using a radioligand binding assay and Scatchard analysis. Budesonide nuclear receptor subfamily 3 group C member 1 Homo sapiens
2 The GCR binding affinity for budesonide was significantly higher in both groups (i.e., lower dissociation constant) than that obtained for dexamethasone. Budesonide nuclear receptor subfamily 3 group C member 1 Homo sapiens
3 CONCLUSION: These data suggest that glucocorticoids such as budesonide, by virtue of their high GCR binding affinities and greater ability to suppress lymphocyte proliferation, may therefore be beneficial in the management of difficult-to-control asthma. Budesonide nuclear receptor subfamily 3 group C member 1 Homo sapiens