Title : Pregnancy induces an increase in angiotensin II type-1 receptor expression in uterine but not systemic artery endothelium.

Pub. Date : 1997 Jan

PMID : 8977439






4 Functional Relationships(s)
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1 AII increases prostacyclin (PGI2) production by uterine artery endothelium from pregnant ewes, and this response is mediated via the AT1 receptor (AT1-R). Epoprostenol angiotensinogen Homo sapiens
2 AII increases prostacyclin (PGI2) production by uterine artery endothelium from pregnant ewes, and this response is mediated via the AT1 receptor (AT1-R). Epoprostenol angiotensinogen Homo sapiens
3 We therefore hypothesize that the increase in uterine artery PGI2 production in response to AII in pregnancy is associated in part with a concomitant increase in AT1-R expression in uterine artery endothelium. Epoprostenol angiotensinogen Homo sapiens
4 We conclude that increased uterine artery endothelial PGI2 responsiveness to AII during pregnancy is indeed associated with a correspondingly marked and localized increase in expression of the endothelial AT1-R receptor. Epoprostenol angiotensinogen Homo sapiens