Title : The role of tyrosine phosphorylation and PTP-1C in CTLA-4 signal transduction.

Pub. Date : 1996 Dec

PMID : 8977326






1 Functional Relationships(s)
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1 Here we demonstrate that phorbol ester phorbol 12-myrislate 13-acetate (PMA), which increases tyrosine phosphorylation by stimulating protein kinase C and p21ras, can overcome the CTLA-4-mediated inhibition of T cell proliferation. Tyrosine Harvey rat sarcoma virus oncogene Mus musculus