Pub. Date : 1996 Dec 1
PMID : 8968086
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | p53-null cells are more sensitive to ultraviolet light only in the presence of caffeine. | Caffeine | tumor protein p53 | Homo sapiens |
| 2 | We have shown previously that p53(-/-) fibroblasts show greater sensitization by caffeine to the lethal effects of ionizing radiation compared with p53(+/+) cells. | Caffeine | tumor protein p53 | Homo sapiens |
| 3 | However, the introduction of 2 mM caffeine led to a sensitization enhancement ratio (at 10% survival) of 1.8 in p53(-/-) cells, but only 1.3 in wild-type (p53+/+) cells. | Caffeine | tumor protein p53 | Homo sapiens |
| 4 | However, the introduction of 2 mM caffeine led to a sensitization enhancement ratio (at 10% survival) of 1.8 in p53(-/-) cells, but only 1.3 in wild-type (p53+/+) cells. | Caffeine | tumor protein p53 | Homo sapiens |
| 5 | The differential sensitivity of p53(-/-) cells to X-rays and caffeine was thought to be due to override of the G2-M block to cell cycle progression. | Caffeine | tumor protein p53 | Homo sapiens |
| 6 | However, for p53(-/-) cells, a greater proportion were in S phase after treatment with caffeine, and a complete loss of S-phase delay was observed after UV irradiation. | Caffeine | tumor protein p53 | Homo sapiens |
| 7 | Greater sensitization of p53(-/-) cells to caffeine could be mediated via override of S-phase delay. | Caffeine | tumor protein p53 | Homo sapiens |