Title : Differential control of 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells.

Pub. Date : 1996 Jun

PMID : 8964847






2 Functional Relationships(s)
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1 Treatment with forskolin (10 mumol/L, 48 h) resulted in a dramatic increase in both cortisol and dehydroepiandrosterone production together with increases in expression of P450c17, P450scc, and 3 beta-HSD as measured at the level of mRNA and activity. Colforsin cytochrome P450 family 11 subfamily A member 1 Homo sapiens
2 Cotreatment with forskolin and AII, however, resulted in a dose-dependent reduction in cortisol and DHEA production concomitant with a marked attenuation of P450scc and P450c17 expression. Colforsin cytochrome P450 family 11 subfamily A member 1 Homo sapiens