Title : Thiol oxidation and cytochrome P450-dependent metabolism of CCl4 triggers Ca2+ release from liver microsomes.

Pub. Date : 1996 Dec 10

PMID : 8961948






3 Functional Relationships(s)
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1 In the presence of NADPH, CCl4 produced a concentration-dependent release of calcium from liver microsomes after a lag period. NADP C-C motif chemokine ligand 4 Rattus norvegicus
2 Inhibition of the CCl4-induced release of calcium by 4-methylpyrazole and by anti-CYP2E1 IgG, and the requirement for NADPH, indicates that CCl4 metabolism is required for the activation of calcium release. NADP C-C motif chemokine ligand 4 Rattus norvegicus
3 Inhibition of the CCl4-induced release of calcium by 4-methylpyrazole and by anti-CYP2E1 IgG, and the requirement for NADPH, indicates that CCl4 metabolism is required for the activation of calcium release. NADP C-C motif chemokine ligand 4 Rattus norvegicus