Title : Mechanisms of oxyradical production in substance P stimulated rheumatoid synovial cells.

Pub. Date : 1996

PMID : 8961380






1 Functional Relationships(s)
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1 Substance P (30 microM) also induced a transient increase in the intracellular Ca2+ concentration ([Ca2+]i) in both synovial A and B cells as measured by a Ca2+ indicator, fura 2, BAPTA-AM and an inositol-1,4-5-triphosphate (IP3) receptor antagonist, heparin, inhibited the substance P induced increase in [Ca2+]i, but they had no effects on oxyradical production. Fura-2 tachykinin precursor 1 Homo sapiens