Pub. Date : 1996 Dec 6
PMID : 8960549
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Benzylidenemalononitrile (BMN) tyrphostins were previously found to be potent inhibitors of EGF receptor (EGFR) tyrosine kinase activity. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 2 | Benzylidenemalononitrile (BMN) tyrphostins were previously found to be potent inhibitors of EGF receptor (EGFR) tyrosine kinase activity. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 3 | Since these compounds were found to compete for the substrate and sometimes with the ATP site and since EGFR acts as a dimer, we prepared a series of dimeric tyrphostins. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |
| 4 | These dimeric tyrphostins were built from two BMN units linked by various spacers and designed to fit the dimeric cross-autophosphorylation signal transduction intermediate of the EGFR tyrosine kinases. | Tyrphostins | epidermal growth factor receptor | Homo sapiens |