Title : Identification of amino acid residues required for a specific interaction between Src-tyrosine kinase and proline-rich region of phosphatidylinositol-3' kinase.

Pub. Date : 1996 Nov 18

PMID : 8955343






2 Functional Relationships(s)
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1 This genetic screen clearly indicates that the interaction between SH3 domain of Fyn and the proline-rich region (residues: 80-104) of PI-3 kinase is highly specific. Proline FYN proto-oncogene, Src family tyrosine kinase Homo sapiens
2 Mutational analysis revealed that amino acid residues Asp92, Tyr93, Arg96 and Thr97 of the SH3 domain of Fyn are essential for interacting with the proline-rich peptide of PI-3 kinase. Proline FYN proto-oncogene, Src family tyrosine kinase Homo sapiens