Title : Inhibitors of Ras farnesylation revert the increased resistance to oxidative stress in K-Ras transformed NIH 3T3 cells.

Pub. Date : 1996 Dec 24

PMID : 8954966






1 Functional Relationships(s)
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1 In fact, inhibition of p21(ras) by transfecting E32-4-2 cells with the transdominant negative mutant of H-ras (L61, S186) led, analogously to lovastatin or (alpha-hydroxyfarnesyl) phosphonic acid treatment, to a strong increase of stress-induced ROS levels. Reactive Oxygen Species Harvey rat sarcoma virus oncogene Mus musculus