Title : Active secretion of drugs from the small intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier.

Pub. Date : 1996 Oct

PMID : 8953513






1 Functional Relationships(s)
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1 ATP depletion by occlusion of the superior mesenteric artery resulted in a clear increase in epithelial permeability to vinblastine, but not to 3-O-methylglucose or acetamide, indicating that vinblastine is secreted by ATP-dependent P-glycoprotein into the lumen. Adenosine Triphosphate ATP binding cassette subfamily B member 1 Homo sapiens