Title : High-risk HPV-positive human cancer cell lines show different sensitivity to cisplatin-induced apoptosis correlated with the p21Waf1/Cip1 level.

Pub. Date : 1996 Nov 12

PMID : 8950204






2 Functional Relationships(s)
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1 Northern blot analyses showed that p53 and p21Waf1/Cip1 mRNA were detectable in all untreated cells, and increasing amounts of these transcripts were identified in all cell lines treated with cisplatin. Cisplatin tumor protein p53 Homo sapiens
2 Our results show that there were differences in sensitivity to cisplatin among four types of high risk HPV-positive cells, possibly due to different levels of p21Waf1/Cip1 up-regulation by functional p53. Cisplatin tumor protein p53 Homo sapiens