Title : The role of reactive oxygen metabolites in the transcriptional regulation of IFN-gamma gene expression by histamine in NK cells following IL-2 stimulation.

Pub. Date : 1996 Sep

PMID : 8948120






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The role of reactive oxygen metabolites in the transcriptional regulation of IFN-gamma gene expression by histamine in NK cells following IL-2 stimulation. Histamine interferon gamma Homo sapiens
2 Both catalase, a scavenger of hydrogen peroxide and histamine, a biogenic amine which inhibits the generation of ROMs by monocytes, strongly abrogated the inhibition of IFN-gamma production. Histamine interferon gamma Homo sapiens
3 We thereby conclude that histamine behaves synergistically with IL-2 at a transcriptional level to induce IFN-gamma even in an admixture of NK cells and monocytes. Histamine interferon gamma Homo sapiens