Title : CYP2D6 is the principal cytochrome P450 responsible for metabolism of the histamine H1 antagonist promethazine in human liver microsomes.

Pub. Date : 1996 Oct

PMID : 8946477






1 Functional Relationships(s)
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1 The promethazine hydroxylase in human liver microsomes was inhibited by SKF-525A, propranolol, sparteine, quinidine and anti-CYP2D6 serum suggesting involvement of a P450 related to CYP2D6. Propranolol cytochrome P450 family 2 subfamily D member 6 Homo sapiens