Title : Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation.

Pub. Date : 1996 Dec 1

PMID : 8943379






2 Functional Relationships(s)
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1 In this study, we demonstrated that STAT4 activation by IL-12 is not unique; IL-12 and IFN-alpha, but not IFN-gamma, induced tyrosine phosphorylation and DNA binding of STAT4. Tyrosine interferon alpha 1 Homo sapiens
2 Thus, STAT4 activation was not IL-12 specific, and IL-12 and IFN-alpha activated STAT4 through both tyrosine and serine phosphorylation. Tyrosine interferon alpha 1 Homo sapiens