Title : Mechanism for aromatase inactivation by a suicide substrate, androst-4-ene-3,6,17-trione. The 4 beta, 5 beta-epoxy-19-oxo derivative as a reactive electrophile irreversibly binding to the active site.

Pub. Date : 1996 Oct 25

PMID : 8937433






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Aromatase is a cytochrome P450 enzyme complex that catalyzes the conversion of androst-4-ene-3,17-dione to estrone through three sequential oxygenations of the 19-methyl group. Androstenedione cytochrome P450 family 19 subfamily A member 1 Homo sapiens