Title : Increased expression of the ETS-related transcription factor FLI-1/ERGB correlates with and can induce the megakaryocytic phenotype.

Pub. Date : 1996 Nov

PMID : 8930402






2 Functional Relationships(s)
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1 We report that TPA-treated K562 cells also express higher levels of FLI-1/ERGB, a member of the ETS family of transcription factors. Tetradecanoylphorbol Acetate Fli-1 proto-oncogene, ETS transcription factor Homo sapiens
2 Furthermore, introduction of a retroviral construct expressing human FLI-1/ERGB into K562 cells induces changes similar to those seen following TPA treatment, including increased adherence to the surface of the culture vessel and altered size and morphology. Tetradecanoylphorbol Acetate Fli-1 proto-oncogene, ETS transcription factor Homo sapiens