Title : Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis.

Pub. Date : 1996 Oct

PMID : 8921985






1 Functional Relationships(s)
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1 The most significant finding is that more than 50% of HCC patients from high aflatoxin exposure areas such as southern Africa and Qidong, China harboured a codon 249 G to T transversion in the p53 tumor suppressor gene, which is found to be consistent with the mutagenic specificity of AFB1 observed in vitro. Aflatoxins tumor protein p53 Homo sapiens