Title : Sequences within the first exon of BCR inhibit the activated tyrosine kinases of c-Abl and the Bcr-Abl oncoprotein.

Pub. Date : 1996 Nov 15

PMID : 8912843






2 Functional Relationships(s)
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1 Our findings indicate that the Abl SH2 binding domain of Bcr in the phosphoserine form inhibits the Bcr-Abl oncoprotein but that tyrosine phosphorylation of this domain of Bcr reverses its inhibitory effects on Bcr-Abl. Phosphoserine BCR activator of RhoGEF and GTPase Homo sapiens
2 Our findings indicate that the Abl SH2 binding domain of Bcr in the phosphoserine form inhibits the Bcr-Abl oncoprotein but that tyrosine phosphorylation of this domain of Bcr reverses its inhibitory effects on Bcr-Abl. Phosphoserine BCR activator of RhoGEF and GTPase Homo sapiens