Pub. Date : 1996 Nov 1
PMID : 8910370
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have previously reported that hydrogen peroxide, an active oxygen species and a cellular oxidant, induces c-Fos and c-Jun mRNA expression and DNA synthesis in vascular smooth muscle cells and that these events require arachidonic acid release and metabolism through the lipoxygenase pathway. | Hydrogen Peroxide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 2 | Hydrogen peroxide and arachidonic acid also induced the expression of c-Fos and c-Jun protein and AP-1 activity. | Hydrogen Peroxide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |
| 3 | Nordihydroguaiaretic acid, an inhibitor of the lipoxygenase pathway, significantly inhibited both hydrogen peroxide and arachidonic acid-stimulated c-Fos and c-Jun protein expression and AP-1 activity. | Hydrogen Peroxide | Jun proto-oncogene, AP-1 transcription factor subunit | Homo sapiens |