Title : Lipid products of phosphoinositide 3-kinase bind human profilin with high affinity.

Pub. Date : 1996 Nov 5

PMID : 8909300






3 Functional Relationships(s)
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1 Moreover, the inhibitory effect of profilin on PLC-gamma 1-mediated PtdIns(4,5)P2 hydrolysis is overcome by PtdIns(3,4)P2 and PtdIns(3,4,5)P3 through a combined effect of PLC-gamma 1 activation and preferential profilin binding. Phosphatidylinositol 4,5-Diphosphate phospholipase C gamma 1 Homo sapiens
2 Moreover, the inhibitory effect of profilin on PLC-gamma 1-mediated PtdIns(4,5)P2 hydrolysis is overcome by PtdIns(3,4)P2 and PtdIns(3,4,5)P3 through a combined effect of PLC-gamma 1 activation and preferential profilin binding. Phosphatidylinositol 4,5-Diphosphate phospholipase C gamma 1 Homo sapiens
3 This D-3 phosphoinositide-mediated regulation may represent a new mechanism for controlling PtdIns(4,5)P2 turnover by PLC-gamma 1. Phosphatidylinositol 4,5-Diphosphate phospholipase C gamma 1 Homo sapiens