Title : Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a potent inhibitor of nuclear transcription factor-kappa B activation by diverse agents.

Pub. Date : 1996 Nov 15

PMID : 8906816






3 Functional Relationships(s)
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1 In the present study, we examined the effect of capsaicin and its analogue, resiniferatoxin, on the activation of NF-kappa B induced by different agents including TNF. Capsaicin tumor necrosis factor Homo sapiens
2 The pretreatment of human myeloid ML-1a cells with capsaicin blocked TNF-mediated activation of NF-kappa B in a dose- and time-dependent manner. Capsaicin tumor necrosis factor Homo sapiens
3 TNF-dependent promoter activity of I kappa B alpha, which contains NF-kappa B binding sites, was also inhibited by capsaicin. Capsaicin tumor necrosis factor Homo sapiens