Title : Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops.

Pub. Date : 1996 Oct

PMID : 8903513






2 Functional Relationships(s)
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1 Four residues in the second intracellular loop (Y136, L137, I139, V140) and one residue in the third intracellular loop (M241) were shown to be crucial for mediating calcium signaling in response to IL-8. Calcium C-X-C motif chemokine ligand 8 Homo sapiens
2 Mutagenesis of the residues in the first intracellular loop had only weak effects on the mobilization of calcium induced by IL-8. Calcium C-X-C motif chemokine ligand 8 Homo sapiens