Title : Inhibitory effect of TMK688 on skin tumor initiation caused by 7,12-dimethylbenz[a]anthracene in relation to inhibition of aryl hydrocarbon hydroxylase activity and Cyp1a1 mRNA induction.

Pub. Date : 1996 Aug

PMID : 8902877






1 Functional Relationships(s)
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Compound Name
Protein Name
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1 Oral administration of TMK688 (30 mg/kg) almost completely suppressed Cyp1a1 mRNA levels in mouse epidermis induced by a topical application of MC (40 mg/kg) or benzo[a]pyrene (200 nmol) to mouse skin. Benzo(a)pyrene cytochrome P450, family 1, subfamily a, polypeptide 1 Mus musculus