Pub. Date : 1996 Nov 1
PMID : 8895746
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alterations in H-ras1 promoter conformation during N-nitroso-N-methylurea-induced mammary carcinogenesis and pregnancy. | Methylnitrosourea | HRas proto-oncogene, GTPase | Rattus norvegicus |
| 2 | We previously demonstrated that H-ras1 oncogene mutations detected in N-nitroso-N-methylurea (NMU)-induced mammary tumors arose as background mutations within rat mammary cells (RMCs) and that NMU promoted the outgrowth of these preexisting mutants. | Methylnitrosourea | HRas proto-oncogene, GTPase | Rattus norvegicus |
| 3 | We previously demonstrated that H-ras1 oncogene mutations detected in N-nitroso-N-methylurea (NMU)-induced mammary tumors arose as background mutations within rat mammary cells (RMCs) and that NMU promoted the outgrowth of these preexisting mutants. | Methylnitrosourea | HRas proto-oncogene, GTPase | Rattus norvegicus |
| 4 | We previously demonstrated that H-ras1 oncogene mutations detected in N-nitroso-N-methylurea (NMU)-induced mammary tumors arose as background mutations within rat mammary cells (RMCs) and that NMU promoted the outgrowth of these preexisting mutants. | Methylnitrosourea | HRas proto-oncogene, GTPase | Rattus norvegicus |
| 5 | We have now detected a putative DNA structure in the H-ras1 promoter of RMCs in vivo that was absent in NMU-induced mammary tumor cells. | Methylnitrosourea | HRas proto-oncogene, GTPase | Rattus norvegicus |
| 6 | We hypothesize that the NMU-induced alterations in promoter conformation irreversibly deregulates H-ras1 expression in initiated cells, thereby increasing the phenotypic penetrance of the conditional H-ras1 mutations. | Methylnitrosourea | HRas proto-oncogene, GTPase | Rattus norvegicus |
| 7 | We hypothesize that the NMU-induced alterations in promoter conformation irreversibly deregulates H-ras1 expression in initiated cells, thereby increasing the phenotypic penetrance of the conditional H-ras1 mutations. | Methylnitrosourea | HRas proto-oncogene, GTPase | Rattus norvegicus |