Title : The simulated binding of (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]meth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses.

Pub. Date : 1996 Oct 25

PMID : 8893840






1 Functional Relationships(s)
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1 A new mode of binding of ACh to AChE was found which involves the carboxyl oxygen of ACh interacting with Gly 118 and 119. Glycine acetylcholinesterase (Cartwright blood group) Homo sapiens