Title : Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain.

Pub. Date : 1996 Oct

PMID : 8887989






5 Functional Relationships(s)
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1 Effect of pindolol on the function of pre- and postsynaptic 5-HT1A receptors: in vivo microdialysis and electrophysiological studies in the rat brain. Pindolol 5-hydroxytryptamine receptor 1A Rattus norvegicus
2 The inhibitory effect of LSD on 5-HT neuronal firing activity was also markedly attenuated in (-)pindolol-treated rats, indicating that somatodendritic 5-HT1A receptors were blocked by (-)pindolol. Pindolol 5-hydroxytryptamine receptor 1A Rattus norvegicus
3 The inhibitory effect of LSD on 5-HT neuronal firing activity was also markedly attenuated in (-)pindolol-treated rats, indicating that somatodendritic 5-HT1A receptors were blocked by (-)pindolol. Pindolol 5-hydroxytryptamine receptor 1A Rattus norvegicus
4 To determine whether (-)pindolol also blocked postsynaptic 5-HT1A receptors in hippocampus, 5-HT and the prototypical 5-HT1A agonist 8-OH-DPAT were applied by microiontophoresis onto CA3 pyramidal neurons following the same treatment. Pindolol 5-hydroxytryptamine receptor 1A Rattus norvegicus
5 Taken together, these results indicate that (-)pindolol can potentiate the effects of an SSRI on extracellular 5-HT concentration by preventing the activation of somatodendritic 5-HT1A autoreceptors resulting from the blockade of the 5-HT transporter in the raphe. Pindolol 5-hydroxytryptamine receptor 1A Rattus norvegicus