Title : The influence of ethnic factors and gender on CYP1A2-mediated drug disposition: a comparative study in Caucasian and Chinese subjects using phenacetin as a marker substrate.

Pub. Date : 1996 Oct

PMID : 8885124






2 Functional Relationships(s)
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1 The influence of ethnic factors and gender on CYP1A2-mediated drug disposition: a comparative study in Caucasian and Chinese subjects using phenacetin as a marker substrate. Phenacetin cytochrome P450 family 1 subfamily A member 2 Homo sapiens
2 To assess potential ethnic and gender-related differences in the expression of cytochrome CYP1A2-mediated activity, the pharmacokinetics of phenacetin (a CYP1A2 substrate) and its metabolite paracetamol were compared in 20 Caucasian and 20 Chinese subjects after administration of a single oral 900 mg phenacetin dose. Phenacetin cytochrome P450 family 1 subfamily A member 2 Homo sapiens