Title : Nitration and inactivation of manganese superoxide dismutase in chronic rejection of human renal allografts.

Pub. Date : 1996 Oct 15

PMID : 8876227






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Immunoprecipitation and amino acid sequencing techniques identified manganese superoxide dismutase, the major antioxidant enzyme in mitochondria, as one of the targets of tyrosine nitration. Tyrosine superoxide dismutase 2 Homo sapiens
2 Exposure of recombinant human manganese superoxide dismutase to peroxynitrite resulted in a dose-dependent (IC50 = 10 microM) decrease in enzymatic activity and concomitant increase in tyrosine nitration. Tyrosine superoxide dismutase 2 Homo sapiens