Pub. Date : 1996 Aug
PMID : 8874655
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhancement of basophil histamine release by interleukin-3: reduced effect in atopic subjects. | Histamine | interleukin 3 | Homo sapiens |
| 2 | The inducing and enhancing effects of interleukin-3 (IL-3) on basophil histamine release in patients with respiratory allergy (n = 28) and in normal subjects (n = 22) were compared. | Histamine | interleukin 3 | Homo sapiens |
| 3 | The inducing and enhancing effects of interleukin-3 (IL-3) on basophil histamine release in patients with respiratory allergy (n = 28) and in normal subjects (n = 22) were compared. | Histamine | interleukin 3 | Homo sapiens |
| 4 | A trend toward higher histamine release after challenge with anti-IgE, FMLP, and IL-3 was found in atopic subjects. | Histamine | interleukin 3 | Homo sapiens |
| 5 | Preincubation of basophils with IL-3 resulted in a dose-dependent increase of anti-IgE- and FMLP-induced histamine release, with a more marked effect in nonatopic than in atopic subjects. | Histamine | interleukin 3 | Homo sapiens |
| 6 | Mean net enhancement of anti-IgE-induced histamine release by 10 ng/ml IL-3 was 2.5 +/- 5% in atopic subjects and 29.6 +/- 4.2% in nonatopic subjects (P < 0.001). | Histamine | interleukin 3 | Homo sapiens |
| 7 | The enhancement of FMLP-induced histamine release by IL-3 was 10.3 +/- 3.9% in atopic patients and 29 +/- 2.4% in nonatopic subjects (P < 0.01). | Histamine | interleukin 3 | Homo sapiens |
| 8 | In atopic subjects, a negative correlation was found between anti-IgE- or FMLP-induced histamine release and net enhancement by IL-3 (r = -0.45, P < 0.02; r = -0.48, P < 0.01, respectively). | Histamine | interleukin 3 | Homo sapiens |
| 9 | The results of this study indicate that in atopic subjects IgE-mediated histamine release can scarcely be enhanced by a basophil response modifier such as IL-3. | Histamine | interleukin 3 | Homo sapiens |