Title : Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation.

Pub. Date : 1996 Oct

PMID : 8873685






2 Functional Relationships(s)
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1 Dextromethorphan is N-demethylated in vitro to 3-methoxymorphinan by human CYP3A4/5. 3-methoxymorphinan cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Urinary excretion of 3-methoxymorphinan was excretion rate-limited in extensive metabolizers of CYP2D6, which necessitated a longer urine collection, 0 to 72 hours, to obtain true MR values for CYP3A. 3-methoxymorphinan cytochrome P450 family 3 subfamily A member 4 Homo sapiens