Title : In vitro interaction of the antipsychotic agent olanzapine with human cytochromes P450 CYP2C9, CYP2C19, CYP2D6 and CYP3A.

Pub. Date : 1996 Mar

PMID : 8866916






1 Functional Relationships(s)
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1 Olanzapine, clozapine, and ketoconazole were all found to non-competitively inhibit 1"-hydroxy midazolam formation, form selective for CYP3A, yielding Ki values of 491, 99 and 0.11 microM, respectively. 1-hydroxymethylmidazolam cytochrome P450 family 3 subfamily A member 4 Homo sapiens