Title : The role of the Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions.

Pub. Date : 1996 Aug

PMID : 8866476






8 Functional Relationships(s)
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1 We previously reported that oxidative damage in yeast lacking copper/zinc superoxide dismutase (SOD1) can be alleviated through mutations in PMR1, encoding a calcium P-type ATPase homologue that also functions in manganese homeostasis. Manganese Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Saccharomyces cerevisiae S288C
2 In an attempt to further understand the relationship between manganese ions, PMR1 and SOD1, we conducted a search for manganese homeostasis genes that interact with PMR1. Manganese Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Saccharomyces cerevisiae S288C
3 In an attempt to further understand the relationship between manganese ions, PMR1 and SOD1, we conducted a search for manganese homeostasis genes that interact with PMR1. Manganese Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Saccharomyces cerevisiae S288C
4 A genomic library was screened for genes that, when overexpressed, suppress the manganese hypersensitivity associated with pmr1 mutations. Manganese Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Saccharomyces cerevisiae S288C
5 A single clone was isolated that reduced manganese toxicity in both the pmr1 mutant and PMR1 wild-type yeast. Manganese Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Saccharomyces cerevisiae S288C
6 A single clone was isolated that reduced manganese toxicity in both the pmr1 mutant and PMR1 wild-type yeast. Manganese Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Saccharomyces cerevisiae S288C
7 Our studies indicate that, like PMR1, CCC1 functions in the homeostasis of both calcium and manganese ions. Manganese Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Saccharomyces cerevisiae S288C
8 We provide a model in which Ccc1p and Pmr1p work together to control the intracellular partitioning of manganese ions. Manganese Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1 Saccharomyces cerevisiae S288C