Pub. Date : 1996 Oct 1
PMID : 8862424
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We observe that, in addition to the membrane targeting signal and the conserved arg-arg residues within the core region, mutations in the proline-rich domain of Nef also affect its ability to associate with the serine kinase activity. | Proline | S100 calcium binding protein B | Homo sapiens |
| 2 | In contrast, the proline-rich region of Nef is found to be involved in mediating efficient proviral DNA synthesis and the enhanced virion-infectivity function, but is not necessary for CD4 down-modulation by Nef. | Proline | S100 calcium binding protein B | Homo sapiens |
| 3 | These findings define three functional domains of Nef that are required for its interaction with the serine kinase activity and suggest that the cellular interaction events via the myristoylation and arg-arg regions of Nef lie upstream of the interaction event via the proline-rich domain. | Proline | S100 calcium binding protein B | Homo sapiens |
| 4 | These findings define three functional domains of Nef that are required for its interaction with the serine kinase activity and suggest that the cellular interaction events via the myristoylation and arg-arg regions of Nef lie upstream of the interaction event via the proline-rich domain. | Proline | S100 calcium binding protein B | Homo sapiens |